Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".

Early in his crime-solving career, Sherlock Holmes attempts to prevent Moriarty from cornering the heroin market.

Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.

A convicted thief in Dartmoor prison hides the location of the stolen Bank of England printing plates inside three music boxes. When the innocent purchasers of the boxes start to be murdered, Holmes and Watson investigate.

In the midst of World War II, Sherlock Holmes rescues the Swiss inventor of a new bomb-sight from the Gestapo and brings him to England, where he quickly falls into the clutches of the evil Professor Moriarty.

When a nobleman is threatened by a family curse on his newly inherited estate, detective Sherlock Holmes is hired to investigate.

Arthur Conan Doyle reveals the story behind Sherlock Holmes and his mysteries by telling about Dr. Joseph Bell, from whom he drew his inspiration, after meeting him as a medical student in Edinburgh. This TV movie served as the pilot for the later released minisseries Murder Rooms: Mysteries of the Real Sherlock Holmes produced by the BBC. The series then picks up with Sir Arthur Conan Doyle's time as a general practitioner in Southsea, solving mysteries with the help of his mentor, Dr Joseph Bell, who is still based in Edinburgh.

Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime. Does it involve a family curse, the crown jewels of England, or something else…

Adventure chases detective Enola Holmes to Malta, where personal and professional dreams collide in a case more tangled and treacherous than any she has faced before.

Now a detective-for-hire like her infamous brother, Enola Holmes takes on her first official case to find a missing girl, as the sparks of a dangerous conspiracy ignite a mystery that requires the help of friends — and Sherlock himself — to unravel.

In London, a secret society led by lawyer Thaddeus Merrydew collects the assets of any of its deceased members and divides them among the remaining members. Society members start dropping like flies. Sherlock Holmes is approached by member James Murphy's widow, who is miffed at being left penniless by her husband. When Captain Pyke is shot, Holmes keys in on his mysterious Chinese widow as well as the shady Merrydew. Other members keep dying: Malcom Dearing first, then Mr. Baker. There is also an attempt on the life of young Eileen Forrester, who became a reluctant society member upon the death of her father. Holmes' uncanny observations and insights are put to the test.

Sherlock Holmes gets the clues he needs to solve a murder, and to prevent another one from occurring, when he finds out that a doctor owns a poisonous snake--the deadly swamp adder. Filmed on the expensive sets leftover from the movie Joan of Arc at Hal Roach Studios in Culver City and produced for the "Your Show Time" series, the short has been released as a solo feature on many DVDs that chronicle classic Sherlock Holmes films..

A young woman turns to Holmes for protection when she's menaced by an escaped killer seeking missing treasure. However, when the woman is kidnapped, Holmes and Watson must penetrate the city's criminal underworld to find her.

Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.

Sherlock Holmes is drawn into the case of Jack the Ripper, who is killing prostitutes in London's East End. Assisted by Dr. Watson, and using information provided by a renowned psychic, Robert Lees, Holmes finds that the murders may have their roots in a Royal indiscretion and that a cover-up is being managed by politicians at the highest level, all of whom happen to be Masons.

Sherlock Holmes and Watson are on the trail of a criminal and scientific mastermind who seems to control monsters and creations which defy belief.

The Good Comrades are a collection of varied gentlemen who crave one thing - solitude. They reside at Drearcliff House, ancestral home of their eldest member. All seems serene and convivial until one by one the members begin to perish in the most grisly of manners. Foul play is suspected by the Good Comrades' insurance agent, who turns to Sherlock Holmes and Dr. John Watson for guidance.

The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.

When a woman is found dead with her throat torn out, the local villagers blame a supernatural monster. But Sherlock Holmes, who gets drawn into the case from nearby Quebec, suspects a human murderer.

When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.