Handle with Care is a 1922 silent comedy of marital complications and mix-ups.

Upon seeing millionaire Lee Brooks's picture in the paper, Julie Le Fabrier, a romantic young model in Madame Swan's dress shop, immediately falls in love with him. Soon afterwards, Julie is sent to the Grand Tides Hotel to deliver a dress to Madame Ricardo, an attractive young woman whose bills are paid by Lee's lovestruck father, Mason Brooks. Having seen her husband, whom she believed to be in South America, on the grounds, Madame Ricardo deserts the hotel, so Julie dons the gown and masquerades as Mason's mistress.

At the death of Count de Beaulieu, his daughter Jeanne learns that her father had been the arch-criminal known as The Phantom. The only other person who knew her father's identity was his lieutenant, Franz Leroux, who now demands that Jeanne marry him in return for his silence.

After his defeat at the hands of "Spider" Flynn, the welterweight champion of Europe, boxer Jimmie Dolan and his trainer, Thomas Jefferson Jones, leave for a principality near Paris. Having lost all their money on the fight, Jimmie accepts Count Conrad's offer to impersonate Prince Frederick in return for a large sum of money.

When Mary and Fannie Graham, daughters of a good mother but a father with criminal instincts, are left motherless, Mary flees from her unhappy surroundings while Fannie, inheriting her father's disposition, remains and is raised as a thief.

Tommy Buckman, the ne'er-do-well son of dime store magnate John Buckman, is given one last chance to succeed by surveying a possible location in New England for the opening of another store in his father's chain. Arriving in the town of Winton, Tommy lands in jail and, disowned by his father, is bailed out by Nina Potter, whose father owns the only dime store in town.

From a Montana mining camp, a young man progresses to the society heights of New York, making his mark publicly as a dancer, but secretly as a gentleman burglar.

Emphatically opposed to Jack Moss, old Mr. McGillicuddy puts the ban on his marriage to his daughter Dolly. The old gentleman is adamant to the appeals of the young lovers and interposes his interference on every occasion, when they get together. McGillicuddy is seized with an attack of the gout, which handicaps him, and it is then Jack arranges with Dolly to elope.

John Hampstead gives up his career as an actor and his actress sweetheart, Marian Dounay, to become a minister in a western town. Marian appears, and failing to win him back she tries to ruin his reputation. Hampstead is accused of stealing some jewelry though actually he is protecting the scapegrace brother of his current sweetheart, Bessie.

A villain attempts to win the love of a pretty fisher girl, who is in love with a village youth. The villain finally kidnaps the girl and carries her out to a rock at low tide, where he ties her. He stands on the shore hoping that the rising water will force her to promise to marry him. The water rises higher and higher, tremendous waves dashing over the girl, and when it seems impossible for her to live another minute her sweetheart arrives with a crowd of the village people and rescues her.

According to Richard Standhope's will, both his daughter Laura and her long-lost twin brother Larry must be reunited by a certain date, or the estate will revert to her avaricious guardian, Andrew Brean. Following Standhope's death, Laura and her sweetheart, Jim Watson, read in her deceased mother's diary that Andrew had broken up the Standhopes' marriage soon after the twins' birth by unjustly accusing Mrs. Standhope of infidelity. Laura was then sent to boarding school, while little Larry, placed in his father's care, was neglected and later became a thief. As Laura and Jim ponder Larry's whereabouts, the house is robbed by none other than Larry, now called "the Kid," and his cohort, "the Snail."

Georgie Burns is a conceited, athletic individual, who has turned his home into a gymnasium. His pretty wife is exceedingly vexed but cannot cure him of his love for strenuous sports. A forlorn tramp comes to the floor begging for a meal, and George promptly knocks him down.

A burlesque of a Spanish courtship, in which two rivals for the hand of a beautiful senorita battle with each other.

Mabel is in love with John, the country boy, but her father wants her to marry a Baron. She is locked up in a room, and her father watches her. John takes a bundle of cloth and makes a big firebrand which he throws into the window, at the same time yelling, "Fire." Dad runs for his life and Mabel jumps through the window into the arms of John, who hurries her to the minister's house. The ceremony is about to take place when Dad and the Baron rush in, and Mabel is led home again.

Si marries a guileless country maid, and receives among his wedding presents a bottle of liquor. The bride samples it in Si's absence, and being unaccustomed to drink, is overcome and falls on the table in a stupor. Si discovers her just as a party of neighbors are coming to congratulate the young couple and hides her in the yard, laying her on a bench. An inquisitive visitor finds her and reports to the constables that Si has killed his wife, and he is apprehended.

Three rivals are aspirants for the hand of Mabel. Dad falls asleep in a rowboat and is set adrift by one, who tries to win favor as a hero by rescuing him, using a motorboat going at lightning speed. He is exposed, however, and his work goes for naught, as Mabel clings to the man of her choice.

The sinister mesmerist Svengali hypnotizes two characters, then dies abruptly in a Trilby segment from David Henderson's Aladdin, Jr. burlesque. Lost.

Nancy Glenn is a pupil in Pop Hogland's school for crooks. When, attired as a boy named "Spider", Nancy fails at her lessons as a pickpocket, Pop decides to pair her with Pliny Drew, a graduate thief and swindler.

When an aviator dies performing in a traveling circus, the circus closes and sideshow con men "Sky-High" Billy Wardell and "Domino" Dominick are arrested for giving out fake watches to wheel of fortune winners. After Domino springs the jail's lock, they jump a freight train and arrive in the next town, where Billy falls in love when Jane Higgenbotham allows them to breakfast on her freshly baked pies.

At the circus, Betty takes a notion to a baby elephant and induces her father to buy it. He takes it on a week's trial. Betty discovers that it is too big a plaything and it is returned. George, her fiancé, hoping to please her, goes to a costumer's and hires an imitation elephant outfit. He induces two of his friends to fill the front and hind legs.