Buck Roberts is leading a wagon train of railroad supplies and Jim Corkle and his henchman Loder are out to stop them by using white men dressed as Indians for the attacks.

When three Texas Rangers try to investigate kidnapped Mexicans being used as forced labor in the mines of Silver Bullet, they are framed for murder by the town's corrupt sheriff.

When he runs for sheriff, Hoppy is beaten by Jerry Doyle, the gutless wonder voted for by every crook in town. When Hoppy moves to have the new sheriff impeached, outlaw leader Tad Hammond hires forty gunslingers to stop him. Stop Hoppy? Hah!

Hoppy and Lucky have been called in to investigate a series of stage holdups. The robbers are taking gold from Colby's mine and Hoppy suspects it may be ex-outlaw Colby himself. When Speedy strikes gold, Hoppy borrows it and announces a gold shipment hoping to catch the gang and their leader.

Hoppy, Lucky and California search for a mine owned by Trudy Pendleton after it was taken from her by thw swindling gambler Ace Gibson. They find the mine and Hoppy fights Gibson over it.

Finishing a trail drive, Hoppy and the boys head to town and immediately get caught up in the conflict between school teacher Miss Abott and next door saloon owner Mawson. When Miss Abott disappears, Hoppy gets a clue to her location and rescues her from Mawson's cabin. It looks like Mawson is the man he wants, but Hoppy finds an item that indicates otherwise.

Sue Morgan gets Hoppy and his friends to join their expedition looking for Indian artifacts. Expedition leader Atwood makes a deal with nearby cattle rustler Morgan to loot the Indian treasures instead and sell them. Hoppy is on to their plan and pretending to leave follows them. Not only is he outnumbered by Morgan's men, but California has himself about to be sacrificed in an Indian ritual.

Before he was killed by Mark Foster's men, Bud Lawton willed part ownership in his ranch to Hoppy and his two pals. When the three arrive they find a fake posing as Lawton. When they expose the imposter, Foster gets the Sheriff to jail them for Lawton's murder.

Joe Weller has instigated a conflict over water rights between two ranchers. The idea is to have the ranchers do each other in then move in and take over. Hoppy and the good guys won't let this happen.

As rustled cattle have mysteriously disappeared, Johnny sends for his friend Hoppy, Hoppy arrives and immediately suspects Dan Slack. Realizing his telegram about Slack was intercepted, he locks up the operator Lafe knowing he can escape. Tailing Lafe he finds a secret entrance to a mine and inside finds the missing cattle. But Slack's men also find him just as the cattle are stampeded through the mine shaft.

Hoppy is busy chasing stagecoach bandits who sing as they rob.

Lee Garvin has eloped with the daughter of a railroad man who didn't approve of the marriage. Hoppy steps in when the young man is framed for murder.

European bad guy Baron Bendor leads some local townsmen in a plot to obtain horses through theft. Hoppy and his sidekicks Lucky and Speedy must find and expose the horse thieves.

Hopalong Cassidy and Johnny Nelson ride to the mountains to help a man and his daughter save their logging business from someone who is sabotaging their efforts.

When Ranger Hoppy's falsely accused young ranger friend is killed while supposedly trying to escape from jail, Hoppy is blamed and drummed out of the Texas Rangers.

A banker is trying to cheat people out of their silver-rich land. Hoppy learns that the banker is in league with an outlaw gang.

At the reading of his late cousin's will, California learns the estate will be divied among whoever remains of the seven relatives. With one already dead, another immediately murdered, and the Lawyer telling them the ranch is almost worthless, Hoppy investigates.

Belle Langtry runs a town being taken over by cattle rustlers. She is also a front for the outlaws, who are led by Steve Fraser. Hoppy gets elected sheriff and cleans up the town with help from the Bar 20 boys.

Hoppy and new sidekick California Carlson head to California to help out Lucky Jenkins.

A fictionalized account of the real-life adventure of the Sager family. Travelling with a wagon train from Missouri to Oregon, things are going well for the Sagers, until father Sager dies from blood poisoning following an Indian attack, and mother Sager dies soon afterward from pneumonia. The leaders of the wagon train decide to send the children back, but the oldest, John (who had been described by all the adults as lazy and worthless), decides to lead his siblings through the wilderness to complete the journey their parents started.