Eitoku Academy is a high school that caters to rich, high-society families. Among the students who attend there are four young men who have the adulation of the entire school, the "Flower 4" (F4). There is spoiled Doumyouji Tsukasa, cool and mysterious Hanazawa Rui, playboy Nishikado Soujirou, and "madam killer" Mimasaka Akira. If these four show any signs of disliking someone, a red tag is put on the locker of that student and they become a target of bullying for the entire school. Makino Tsukushi is from a middle-class family, attending because her parents asked her to. Her goal is to keep her head down until she can graduate, but her plans are soon made impossible as she is thrown into the world of the F4. Doumyouji falls for Tsukushi for her fierce independence and willingness to stand up to him, but Tsukushi likes the quiet Hanazawa Rui....